Estudios

Clinical signs of essential fatty acid deficiency include a dry scaly rash, decreased growth in infants and children, increased susceptibility to infection, and poor wound healing.…

Linus Pauling Institute, Oregon State University (2026). Essential Fatty Acids. https://lpi.oregonstate.edu/mic/other-nutrients/essential-fatty-acids

Classical essential fatty acid deficiency in healthy individuals in the United States is virtually nonexistent. Clinical signs of essential fatty-acid deficiency are usually only found in patients receiving parenteral nutrition that lacks P…

NIH Office of Dietary Supplements (2026). Omega-3 Fatty Acids - Health Professional Fact Sheet.

Evidence indicates that strains such as Lactobacillus paracasei K71, L. plantarum IS-10506, and L. acidophilus L-92 can moderately reduce clinical severity and improve immunological markers in both children and adults with AD.…

Sędziak O, Gaweł K, Klimczyk K, et al. (2026) Probiotics in atopic dermatitis: A systematic literature review. Forum Dermatologicum 12:e05026025

The findings of this umbrella systematic review indicate that probiotic supplementation holds promise as an adjunctive strategy to improve oral health by modulating microbial markers, reducing halitosis-related outcomes, and slowing caries …

Tang, Z., Deng, Y., Guo, G. & Zhou, L. (2026). The effects of probiotics intervention on oral health outcomes: a comprehensive umbrella review of meta-analyses. Frontiers in Oral Health, 7, 1768508. DOI: 10.3389/froh.2026.1768508

Fifteen RCTs (n = 855) showed curcumin/turmeric supplementation significantly reduced SBP (WMD: -2.69 mmHg; 95% CI: -3.84 to -1.55; p < 0.001).…

Bahari, H., Goudarzi, K., Karimi, E., Mahdi Vatankhah, A., Asadi, Z. (2026). Antihypertensive Effects of Curcumin/Turmeric Supplementation in Prediabetes and Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Endocrinology, Diabetes & Metabolism, 9(1), e70145. DOI: 10.1002/edm2.70145

132 moderate drug interactions reported with curcumin, including commonly prescribed Spanish medications: omeprazole, atorvastatin, metformin, levothyroxine. No major or contraindicated interactions identified.…

Drugs.com Drug Interaction Checker. Curcumin 95 (turmeric) interactions. Accessed 2026.

Versus placebo, melatonin reduced attack duration (MD -4.98 h; 95% CI -9.30 to -0.67; p = 0.02), headache days (MD -1.54 days; 95% CI -2.50 to -0.58; p<0.001).…

Abouelmagd ME, Aldemerdash MA, Khatatbeh AA, et al. (2026) Efficacy and safety of melatonin in migraine prophylaxis: a systematic review and meta-analysis of randomized controlled trials. Current Pain and Headache Reports. DOI: 10.1007/s11916-025-01461-5

Exercise performance outcomes were categorized into four domains: explosive power performance (anaerobic power output), endurance performance (aerobic capacity), speed performance, and strength performance.…

Timing-dependent effects of melatonin supplementation on exercise performance and exercise-induced muscle damage: a systematic review and meta-analysis. Frontiers in Nutrition. 2026; DOI: 10.3389/fnut.2026.1742464

Meta-analysis of 10 RCTs (12 trials) found melatonin supplementation significantly increased HDL-C (WMD = 1.87 mg/dL, p = 0.025), reduced malondialdehyde (MDA: -1.28 μmol/L, p = 0.039), and improved sleep quality in CKD patients.…

Bagci Y, Baltaci AK, Mogulkoc R, Celik S, Pala R (2023) The effect of melatonin supplementation on lipid profile, oxidative stress, inflammatory marker, and sleep quality in patients with chronic kidney disease: a GRADE assessed meta-analysis. Frontiers in Nutrition. DOI: 10.3389/fnut.2026.1772877

Compared with placebo, vitamin D did not reduce any CVD events (RR = 0.95, 95%CI: 0.88–1.04), CVD mortality (RR = 1.04, 95%CI: 0.871–1.242), myocardial infarction event (RR = 0.96, 95%CI: 0.83–1.11), or myocardial infarction mortality.…

Qudah T, Al-Damook N, Abu Hait K, Abumweis S (2026). Vitamin D supplementation and cardiovascular disease events: a systematic review and pooled meta-analysis of randomized clinical trials. Applied Physiology, Nutrition, and Metabolism. 51:1-13. https://doi.org/10.1139/apnm-2025-0158

Recent RCTs and meta-analyses suggest that the protective effects of omega-3 fatty acids are not consistent; they seem to be most effective in early disease progression or in high-risk groups, including carriers of APOE 4.…

Kalamara T, Dodos K, Georgakopoulou V, et al. (2025) Cognitive efficacy of omega-3 fatty acids in Alzheimer's disease: a systematic review and meta-analysis. Biomedical Reports 22:62. DOI: 10.3892/br.2025.1849

Each 2000 mg/d omega-3 supplementation showed a significant improvement in attention (SMD: 0.98; 95%CI: 0.41,1.54; GRADE = low), perceptual speed (SMD: 0.50; 95%CI: 0.05,0.95; GRADE = moderate), language, primary memory, visuospatial functi…

Shabbidar S, Fatahi S, Ghoreishy SM, et al. (2025) A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive function. Scientific Reports 15:16129. DOI: 10.1038/s41598-025-16129-8

Consistent with findings from the VITAL trial, the Alliance trial, the study by Kanto et al., and several large prospective cohort studies, our results showed no significant association between omega-3 fatty acid consumption and CRC inciden…

Alamelumangapuram CB, et al. (2025) Exploring the Role of Omega Fatty Acids in Colorectal Cancer—A Systematic Review. Open Journal of Gastroenterology

On the basis of the data from the PLCO trial, this study found that Omega-3 fatty acid intake is linearly negatively correlated with the overall risk of prostate cancer, that is, the higher the intake, the lower the risk.…

Liu Y, et al. (2025) Dietary Omega-3 intake may slow prostate cancer progression and reduce mortality risk: evidence from prostate, lung, colorectal, and ovarian cancer screening trial. Frontiers in Nutrition

Essential fatty acid deficiency can be seen in patients with cystic fibrosis. Although some deficient patients are asymptomatic, others can have problems with alopecia, skin rashes, easy bruising, increased infections, and poor growth.…

ScienceDirect Topics (2025). Essential Fatty Acid Deficiency - an overview. https://www.sciencedirect.com/topics/medicine-and-dentistry/essential-fatty-acid-deficiency

In skin models of psoriasis, wounds, dermatitis, and melanoma, topical ω-3 PUFAs showed an overall beneficial effect associated with the anti-inflammatory properties of these compounds.…

Mateu-Arrom L et al. (2025). Therapeutic Benefits of Topical Omega‐3 Polyunsaturated Fatty Acids in Skin Diseases and Cosmetics: An Updated Systematic Review. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.70341

Magnesium intake resulted in a reduction in systolic BP of −2.81 mm Hg (95% CI, −4.32 to −1.29) and diastolic BP by −2.05 mm Hg (95% CI, −3.23 to −0.88) compared with placebo.…

Argeros Z, Xu X, Bhandari B, Harris K, Touyz RM, Schutte AE. Magnesium supplementation and blood pressure: a systematic review and meta-analysis of randomized controlled trials. Hypertension. 2025. doi:10.1161/HYPERTENSIONAHA.125.25129

A total of 24 RCTs with 3,373 participants were included. We found that magnesium may reduce the risk of POAF compared to the control group (relative risk [RR]: 0.55; 95% confidence interval [CI]: 0.41, 0.74; low certainty).

Ghazizadeh S, Malektojari A, Javidfar Z, Lahuti S, Shokraei R, Zeinaee M, et al. Magnesium for Prevention of New-onset Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. CJC Open. 2025;7(1):35-45. doi:10.1016/j.cjco.2024.10.008

This study evaluated the effects of magnesium (Mg) supplementation on glycaemic control in type 2 diabetes mellitus through a meta-analysis of 23 randomised controlled trials involving 1,345 participants.…

Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A systematic review and meta-analysis. (2025) PMC article.

Twenty-seven publications including 95,933 participants were included in the meta-analysis. The relative risk summary of metabolic syndrome for highest versus lowest intake of magnesium was 0.79 (95% confidence interval [CI]: 0.71-0.88) for…

Yoon JH, Park JS, Kang SM, et al. (2025) Intake or Blood Levels of Magnesium and Risk of Metabolic Syndrome: A Meta-Analysis of Observational Studies. Nutrients. 17(10):1667. doi:10.3390/nu17101667

Systematic review of 31 RCTs involving 3254 participants found insufficient evidence to support the effects of magnesium supplementation on PMS-related psychological symptoms.…

Hanson MA, Cox BJ, Developmentally Programmed Disease Group. (2025) Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age: a systematic review of randomized controlled trials. Nutrition Reviews 83:280-296.

Probiotics significantly increased the likelihood of clinical remission in patients with active CD (RR: 1.27, 95% CI: 1.09–1.47, p = 0.002). However, no significant effect on clinical relapse was found in patients in remission (RR: 0.93, 95…

Tang F, Sulaimi SN, Loi KN, et al. (2025) Efficacy and safety probiotics as adjuvant treatment for Crohn's disease: a meta-analysis of randomized controlled trials. Clin Nutr ESPEN. doi: 10.1016/j.clnesp.2024.11.022

Probiotic therapy was associated with improvement in abdominal pain (SMD 0.63; 95% CI: 0.38-0.88). For bloating, probiotics demonstrated a small trend toward improvement (SMD 0.158; 95% CI: -0.107 to 0.422), although this did not reach stat…

Alamoudi JA, Alkhattabi NA, Alqassim AY, et al. (2025) The Impact of Probiotics on Clinical Outcomes in Diverticular Disease: A Systematic Review and Meta-Analysis. J Clin Med. 15(1):88. doi: 10.3390/jcm15010088

Umbrella meta-analysis of 35 studies showed that supplementation with probiotics reduced NEC and related mortality. Probiotic supplementation can be recognized as a NEC-preventing approach in preterm and very preterm infants, particularly m…

Han P, Zhang P, Ren Y (2025) The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis and related mortality: results from an umbrella meta-analysis on meta-analyses of randomized controlled trials. BMC Gastroenterology 25:245

Cochrane review of 24 studies (7077 mother-infant pairs) found probiotics given to newborns may slightly reduce development of eczema in infants by age 2 years, but evidence is not high quality.…

Wang HZ, Hayles EH, Fiander M, Sinn JK, Osborn DA (2025) Probiotics in infants for prevention of allergic disease. Cochrane Database of Systematic Reviews 6:CD006475

Systematic review and meta-analysis of 37 studies found probiotics supplementation during pregnancy and infancy reduced risk of total food allergy (RR 0.79, 95% CI 0.63-0.99), cow-milk allergy (RR 0.51, 95% CI 0.29-0.88), and egg allergy (R…

Jiang L, Zhang L, Xia J, et al (2025) Probiotics supplementation during pregnancy or infancy on multiple food allergies and gut microbiota: a systematic review and meta-analysis. Nutrition Reviews 83:e25-e41

Meta-analysis showed probiotics significantly reduced acute asthma episodes with risk ratio of 0.38 (95% CI: 0.26–0.56, p < 0.00001) and improved FEV1/FVC ratios (MD = 5.70, 95% CI: 1.93–9.47, p < 0.003) compared to the control group.

Liu Y, Zhang Y, Li Y, et al. (2025) Probiotics for children with asthma: a systematic review and meta-analysis. Frontiers in Pediatrics 13:1577152. doi:10.3389/fped.2025.1577152

Four randomized controlled trials involving 227 participants were analyzed, showing that probiotic supplementation reduced acne severity scores (OR 0.48; 95% CI 0.29-0.79) and non-inflammatory lesion counts (mean difference (MD) −4.62; 95% …

Mohamed M, Ullah A, Hassan R, et al. (2025) The Impact of Probiotics on Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials. Cureus 17(11):e97010. doi:10.7759/cureus.97010

Overall, these findings suggest that probiotic supplementation exerts a beneficial effect on inflammatory status in patients with CAD. The evidence highlights its potential in reducing systemic inflammation and oxidative stress, as reflecte…

Al-Rasheed NM et al. (2025) Probiotic Supplementation and Inflammatory Status in Coronary Artery Disease: A Systematic Review and Meta-Analysis. Nutrients, 17(20), 4912. DOI: 10.3390/nu17204912

Probiotics, particularly monotherapy for LDL and combination therapy for HDL, exhibited potential to improve lipid profiles in CHD patients. However, further research is needed to address existing limitations and confirm efficacy.

Wang J et al. (2025) The beneficial effects of probiotics on patients with coronary heart disease: a systematic review and meta-analysis. Frontiers in Nutrition, 12, 1612021. DOI: 10.3389/fnut.2025.1612021